It is a version with simultaneous 2 player support. In addition, there are other changes:
Life gauges are shown with visible bars, where Duke and bosses all have 11 bars or life.
In English version, it is no longer possible to refill life bar by adding credits after completing Mission 1.
With the exception of Mission 9, there are more enemies on screen, including boss battles.
In high score entry screen, a countdown timer is shown.
A top scientist decides to utilise a secret formula to develop his very own army of evil mutant warriors, so he can become ruler of the world. It is up to Dynamite Duke: a man who is armed with a cybernetic arm along with a machine gun.
Arcade version has 9 stages, while Genesis version only has 6 stages.
Levi Buchanan of IGN rated the Genesis game a 5.0 (Meh) for a dismal value, 30 minutes of play value.